RESOURCES

Accelerating TCE Drug Development with Humanized Mouse Models

T-cell engagers (TCEs) are innovative bispecific antibodies designed to bind simultaneously to tumor-associated antigens (TAAs) and the CD3 receptor on T-cells. Several TCE drugs have already been approved, with seven bispecific antibodies targeting indications such as multiple myeloma and diffuse large B-cell lymphoma (DLBCL), focusing on markers like BCMA, GPRC5D, CD20, and CD19. In the realm of solid tumors, two TCE bispecific antibodies have received approval: Tebentafusp (Immunocore, January 2022, targeting CD3×GP100) and Tarlatamab (Amgen, May 2024, targeting CD3×DLL3). The accelerated approval of Tarlatamab has spurred increased interest in TCE bispecific antibodies for drug development in the solid tumor space. However, significant unmet clinical needs remain, especially for TCE bispecific antibodies targeting solid tumors.

To address this gap, GemPharmatech has established a comprehensive preclinical pharmacology and efficacy evaluation platform, offering a range of in vivo tumor models to support the development of TCE-based therapies.

Mouse Models for Studying Anti-PD-1 Resistance

Immune checkpoint inhibitors targeting PD-1/PD-L1 have revolutionized cancer treatment, offering broad-spectrum efficacy, prolonged durability, and relatively low toxicity[1]. Despite these advancements, the response rates in many cancers remain disappointing, often below 30%[2]. A significant proportion of patients experience partial responses or worse — eventually developing resistance leading to disease progression. These challenges highlight the urgent need for developing novel therapies to overcome anti-PD-1 resistance. This blog will explore how GemPharmatech has developed its own models of anti-PD-1 resistance.

New Publications on the MAPK Signaling Cascade Using GemPharmatech Mice

New Publication on Humanized Mouse Tumor Models

Mouse models to unlock the secrets of aging

How Humanized Mouse Models Can Help Develop New Treatments for HBV

AG129 Mice to Help Dengue Virus-Related Research

World Hepatitis Day

Hepatitis refers to inflammation of the liver, primarily caused by viruses, but also influenced by factors such as alcohol, drugs, and autoimmune diseases. It is a serious disease and formidable adversary, but with sufficient knowledge and preventive measures, its threat can be controlled. GemPharmatech has created numerous hepatitis models to help accelerate research aimed at treating this increasingly prevalent disease.

NAFLD is now MASLD: Why has this Disease been Renamed?